Associate Scientist, DMPK/Clinical Pharmacology

Mersana Therapeutics Cambridge, MA

About the Job

Mersana Therapeutics, Inc. (Nasdaq: MRSN) is a clinical stage biotechnology company focused on developing novel Antibody Drug Conjugates (ADCs) leveraging our highly-differentiated best-in-class drug conjugation platform. Our lead program XMT-1522, an investigational antibody drug conjugate against HER2 expressing tumors, demonstrated superior efficacy in a broad range of pre-clinical models not responsive to available HER2 therapies. Phase 1 clinical studies are underway for XMT-1522 and is being co-developed by Mersana and Takeda. Mersana will be responsible for commercialization in the United States and Canada; Takeda will be responsible throughout the rest of world. A second program, XMT-1536, an investigational antibody drug conjugate against Napi2B expressing tumors, demonstrated in pre-clinical models superior efficacy not achievable with traditional ADC platforms and an IND is expected in late 2017. Mersana is well positioned to continue to grow and advance its pipeline based upon our proprietary ADC platform. Mersana has granted access to its ADC platform for use in a small number of programs to Merck Serono and Takeda. These strategic partners are progressing multiple preclinical programs in close collaboration with Mersana. 

Mersana seeks individuals who share our excitement about the possibilities our proprietary drug conjugation platform offers and our commitment to making a difference in patients. At Mersana we have a highly collaborative culture and believe that our collective ability to make a difference exceeds the sum of our individual efforts.

What’s in it for you?

In this role, you will have an opportunity to work closely with both clinical and nonclinical peers and grow your experience in DMPK and clinical pharmacology. This role will have a great impact to Mersana at this extraordinary stage of the company’s development, specifically, you will assist in non-clinical & clinical PK, PD data analysis, and spend some of your time interacting with internal and external partners to manage reagents & documents. You will be immersed in a learning organization, where you can bring an open mind and be ready to learn new concepts and tools.


How do you know if you’re the right fit?

This will be a great role for you if you are a self-motivated, driven, and you enjoy building new processes in data analysis and reagent & document management.

Your experience will span along the range of the following responsibilities:

  • Responsible for non-compartmental analyses (NCA), creation of tables, figures and listings (TFL), for both non-clinical and clinical PK data
  • Assist in data exploration and visualizations of PK data, writing and compiling internal documents (e.g. PK summary, TK reports)
  • Assist on efforts involving the development of standardization and process optimization
  • Conduct QC check of outputs and results in the documents
  • Manage critical/key reagent inventory at Mersana
  • Manage assay development and analysis efforts at reference labs for preclinical and clinical research
  • Coordinate and work with various line functions with respect to reagent supplies
  • Oversee physical and electronic archiving of project documents, including organizing and maintaining
  • Other duties as required

The other stuff

This is typically a role best suited for Master’s level candidates in Pharmaceutical Sciences, Biostatistics, Mathematics, Engineering, or in a related scientific discipline, who possess some experience in drug research and development. You’ll have software skills, including Microsoft office suite (Word, Excel and PowerPoint), and data analysis software (e.g. Phoenix WinNonLin, S-Plus/R). You’ll possess experience working with generating analysis datasets, data pooling and data graphical representation. You’ll demonstrate excellent verbal and written communication skills.

Position is eligible for bonus, option awards and benefits including medical, dental and life insurance, 401(k) with employer match, vacation and paid holidays. The candidate must be authorized to work within the US.

Mersana Therapeutics, Inc. is an equal opportunity employer.

Please submit resume to and reference "Associate Scientist, DMPK" in the subject field.